May there be a run on Yoplait and Chobani following a brand new well being examine about yogurt?
Mass Normal Brigham researchers have discovered that consuming yogurt over time can assist shield towards colorectal most cancers by adjustments within the intestine microbiome.
The researchers found that long-term consumption of two or extra servings per week of yogurt was tied to decrease charges of proximal colorectal most cancers constructive for Bifidobacterium — a bacterial species present in yogurt.
The examine confirmed that the bacterial species was fairly widespread: About 30% of sufferers with colorectal most cancers had detectable Bifidobacterium of their tumor tissue.
“Our study provides unique evidence about the potential benefit of yogurt,” mentioned corresponding writer Shuji Ogino, of the Division of Pathology at Brigham and Ladies’s Hospital.
“My lab’s approach is to try to link long-term diets and other exposures to a possible key difference in tissue, such as the presence or absence of a particular species of bacteria,” added Ogino, who’s additionally a professor at Harvard T.H. Chan Faculty of Public Health. “This kind of detective work can increase the strength of evidence connecting diet to health outcomes.”
Ogino’s crew is making an attempt to determine the chance elements and environmental exposures which might be behind the rise of early-onset colorectal most cancers.
To conduct their examine, the researchers used knowledge from two U.S.-wide potential cohort research often known as the Nurses’ Health Examine (NHS) and the Health Professionals Observe-up Examine (HPFS). The research have adopted greater than 100,000 feminine registered nurses and 51,000 male well being professionals.
Members have been tracked since 1976 for NHS and 1986 for HFPS, answering repeated questionnaires about life-style elements and illness outcomes — together with questions on common each day consumption of plain and flavored yogurt, in addition to different dairy merchandise.
The researchers additionally checked tissue samples for individuals with confirmed circumstances of colorectal most cancers, measuring the quantity of Bifidobacterium DNA in tumor tissue.
The scientists discovered 3,079 documented circumstances of colorectal most cancers within the two examine teams. Info on Bifidobacterium content material was out there in 1,121 colorectal most cancers circumstances. Amongst these, 346 circumstances (31%) have been Bifidobacterium-positive, and 775 circumstances (69%) have been Bifidobacterium-negative.
The researchers didn’t see a big connection between long-term yogurt consumption and general colorectal most cancers incidence, however they did see an affiliation in Bifidobacterium-positive tumors — with a 20% decrease charge of incidence for individuals who consumed two or extra servings of yogurt per week.
This decrease charge was pushed by decrease incidence of Bifidobacterium-positive proximal colon most cancers — a sort of colorectal most cancers that happens in the suitable aspect of the colon. Research have discovered that sufferers with proximal colon most cancers have worse survival outcomes than sufferers with distal cancers.
“It has long been believed that yogurt and other fermented milk products are beneficial for gastrointestinal health,” mentioned co-senior writer Tomotaka Ugai, of the Division of Pathology on the Brigham, and the Division of Epidemiology on the Harvard T.H. Chan Faculty of Public Health. “Our new findings suggest that this protective effect may be specific for Bifidobacterium-positive tumors.”
The researchers consider that long-term yogurt consumption might cut back the chance of proximal colon most cancers by altering the intestine microbiome, together with Bifidobacterium.
Nonetheless, they notice that additional analysis that brings collectively fundamental science and inhabitants well being research is required to attract a definitive conclusion.
“This paper adds to the growing evidence that illustrates the connection between diet, the gut microbiome, and risk of colorectal cancer,” mentioned co-author Andrew Chan, of the Scientific and Translational Epidemiology Unit at Massachusetts Normal Hospital. “It provides an additional avenue for us to investigate the specific role of these factors in the risk of colorectal cancer among young people.”
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